# Random walks

A college professor of mine proposed a restaurant venture to our class. He taught statistical mechanics, the physics of many-particle systems. Examples range from airplane fuel to ice cubes to primordial soup. Such systems contain 1024 particles each—so many particles that we couldn’t track them all if we tried. We can gather only a little information about the particles, so their actions look random.

So does a drunkard’s walk. Imagine a college student who (outside of the pandemic) has stayed out an hour too late and accepted one too many red plastic cups. He’s arrived halfway down a sidewalk, where he’s clutching a lamppost, en route home. Each step has a 50% chance of carrying him leftward and a 50% chance of carrying him rightward. This scenario repeats itself every Friday. On average, five minutes after arriving at the lamppost, he’s back at the lamppost. But, if we wait for a time $T$, we have a decent chance of finding him a distance $\sqrt{T}$ away. These characteristic typify a simple random walk.

Random walks crop up across statistical physics. For instance, consider a grain of pollen dropped onto a thin film of water. The water molecules buffet the grain, which random-walks across the film. Robert Brown observed this walk in 1827, so we call it Brownian motion. Or consider a magnet at room temperature. The magnet’s constituents don’t walk across the surface, but they orient themselves according random-walk mathematics. And, in quantum many-particle systems, information can spread via a random walk.

So, my statistical-mechanics professor said, someone should open a restaurant near MIT. Serve lo mein and Peking duck, and call the restaurant the Random Wok.

This is the professor who, years later, confronted another alumna and me at a snack buffet.

“You know what this is?” he asked, waving a pastry in front of us. We stared for a moment, concluded that the obvious answer wouldn’t suffice, and shook our heads.

“A brownie in motion!”

Not only pollen grains undergo Brownian motion, and not only drunkards undergo random walks. Many people random-walk to their careers, trying out and discarding alternatives en route. We may think that we know our destination, but we collide with a water molecule and change course.

Such is the thrust of Random Walks, a podcast to which I contributed an interview last month. Abhigyan Ray, an undergraduate in Mumbai, created the podcast. Courses, he thought, acquaint us only with the successes in science. Stereotypes cast scientists as lone geniuses working in closed offices and silent labs. He resolved to spotlight the collaborations, the wrong turns, the lessons learned the hard way—the random walks—of science. Interviewees range from a Microsoft researcher to a Harvard computer scientist to a neurobiology professor to a genomicist.

You can find my episode on Instagram, Apple Podcasts, Google Podcasts, and Spotify. We discuss the bridging of disciplines; the usefulness of a liberal-arts education in physics; Quantum Frontiers; and the delights of poking fun at my PhD advisor, fellow blogger and Institute for Quantum Information and Matter director John Preskill

# Love in the time of thermo

An 81-year-old medical doctor has fallen off a ladder in his house. His pet bird hopped out of his reach, from branch to branch of a tree on the patio. The doctor followed via ladder and slipped. His servants cluster around him, the clamor grows, and he longs for his wife to join him before he dies. She arrives at last. He gazes at her face; utters, “Only God knows how much I loved you”; and expires.

I set the book down on my lap and looked up. I was nestled in a wicker chair outside the Huntington Art Gallery in San Marino, California. Busts of long-dead Romans kept me company. The lawn in front of me unfurled below a sky that—unusually for San Marino—was partially obscured by clouds. My final summer at Caltech was unfurling. I’d walked to the Huntington, one weekend afternoon, with a novel from Caltech’s English library.1

What a novel.

You may have encountered the phrase “love in the time of corona.” Several times. Per week. Throughout the past six months. Love in the Time of Cholera predates the meme by 35 years. Nobel laureate Gabriel García Márquez captured the inhabitants, beliefs, architecture, mores, and spirit of a Colombian city around the turn of the 20th century. His work transcends its setting, spanning love, death, life, obsession, integrity, redemption, and eternity. A thermodynamicist couldn’t ask for more-fitting reading.

Love in the Time of Cholera centers on a love triangle. Fermina Daza, the only child of a wealthy man, excels in her studies. She holds herself with poise and self-assurance, and she spits fire whenever others try to control her. The girl dazzles Florentino Ariza, a poet, who restructures his life around his desire for her. Fermina Daza’s pride impresses Dr. Juvenal Urbino, a doctor renowned for exterminating a cholera epidemic. After rejecting both men, Fermina Daza marries Dr. Juvenal Urbino. The two personalities clash, and one betrays the other, but they cling together across the decades. Florentino Ariza retains his obsession with Fermina Daza, despite having countless affairs. Dr. Juvenal Urbino dies by ladder, whereupon Florentino Ariza swoops in to win Fermina Daza over. Throughout the book, characters mistake symptoms of love for symptoms of cholera; and lovers block out the world by claiming to have cholera and self-quarantining.

As a thermodynamicist, I see the second law of thermodynamics in every chapter. The second law implies that time marches only forward, order decays, and randomness scatters information to the wind. García Márquez depicts his characters aging, aging more, and aging more. Many characters die. Florentino Ariza’s mother loses her memory to dementia or Alzheimer’s disease. A pawnbroker, she buys jewels from the elite whose fortunes have eroded. Forgetting the jewels’ value one day, she mistakes them for candies and distributes them to children.

The second law bites most, to me, in the doctor’s final words, “Only God knows how much I loved you.” Later, the widow Fermina Daza sighs, “It is incredible how one can be happy for so many years in the midst of so many squabbles, so many problems, damn it, and not really know if it was love or not.” She doesn’t know how much her husband loved her, especially in light of the betrayal that rocked the couple and a rumor of another betrayal. Her husband could have affirmed his love with his dying breath, but he refused: He might have loved her with all his heart, and he might not have loved her; he kept the truth a secret to all but God. No one can retrieve the information after he dies.2

Love in the Time of Cholera—and thermodynamics—must sound like a mouthful of horseradish. But each offers nourishment, an appetizer and an entrée. According to the first law of thermodynamics, the amount of energy in every closed, isolated system remains constant: Physics preserves something. Florentino Ariza preserves his love for decades, despite Fermina Daza’s marrying another man, despite her aging.

The latter preservation can last only so long in the story: Florentino Ariza, being mortal, will die. He claims that his love will last “forever,” but he won’t last forever. At the end of the novel, he sails between two harbors—back and forth, back and forth—refusing to finish crossing a River Styx. I see this sailing as prethermalization: A few quantum systems resist thermalizing, or flowing to the physics analogue of death, for a while. But they succumb later. Florentino Ariza can’t evade the far bank forever, just as the second law of thermodynamics forbids his boat from functioning as a perpetuum mobile.

Though mortal within his story, Florentino Ariza survives as a book character. The book survives. García Márquez wrote about a country I’d never visited, and an era decades before my birth, 33 years before I checked his book out of the library. But the book dazzled me. It pulsed with the vibrancy, color, emotion, and intellect—with the fullness—of life. The book gained another life when the coronavius hit. Thermodynamics dictates that people age and die, but the laws of thermodynamics remain.3 I hope and trust—with the caveat about humanity’s not destroying itself—that Love in the Time of Cholera will pulse in 350 years.

What’s not to love?

1Yes, Caltech has an English library. I found gems in it, and the librarians ordered more when I inquired about books they didn’t have. I commend it to everyone who has access.

2I googled “Only God knows how much I loved you” and was startled to see the line depicted as a hallmark of romance. Please tell your romantic partners how much you love them; don’t make them guess till the ends of their lives.

3Lee Smolin has proposed that the laws of physics change. If they do, the change seems to have to obey metalaws that remain constant.

# If the (quantum-metrology) key fits…

My maternal grandfather gave me an antique key when I was in middle school. I loved the workmanship: The handle consisted of intertwined loops. I loved the key’s gold color and how the key weighed on my palm. Even more, I loved the thought that the key opened something. I accompanied my mother to antique shops, where I tried unlocking chests, boxes, and drawers.

My grandfather’s antique key

I found myself holding another such key, metaphorically, during the autumn of 2018. MIT’s string theorists had requested a seminar, so I presented about quasiprobabilities. Quasiprobabilities represent quantum states similarly to how probabilities represent a swarm of classical particles. Consider the steam rising from asphalt on a summer day. Calculating every steam particle’s position and momentum would require too much computation for you or me to perform. But we can predict the probability that, if we measure every particle’s position and momentum, we’ll obtain such-and-such outcomes. Probabilities are real numbers between zero and one. Quasiprobabilities can assume negative and nonreal values. We call these values “nonclassical,” because they’re verboten to the probabilities that describe classical systems, such as steam. I’d defined a quasiprobability, with collaborators, to describe quantum chaos.

David Arvidsson-Shukur was sitting in the audience. David is a postdoctoral fellow at the University of Cambridge and a visiting scholar in the other Cambridge (at MIT). He has a Swedish-and-southern-English accent that I’ve heard only once before and, I learned over the next two years, an academic intensity matched by his kindliness.1 Also, David has a name even longer than mine: David Roland Miran Arvidsson-Shukur. We didn’t know then, but we were destined to journey together, as postdoctoral knights-errant, on a quest for quantum truth.

David studies the foundations of quantum theory: What distinguishes quantum theory from classical? David suspected that a variation on my quasiprobability could unlock a problem in metrology, the study of measurements.

Suppose that you’ve built a quantum computer. It consists of gates—uses of, e.g., magnets or lasers to implement logical operations. A classical gate implements operations such as “add 11.” A quantum gate can implement an operation that involves some number $\theta$ more general than 11. You can try to build your gate correctly, but it might effect the wrong $\theta$ value. You need to measure $\theta$.

How? You prepare some quantum state $| \psi \rangle$ and operate on it with the gate. $\theta$ imprints itself on the state, which becomes $| \psi (\theta) \rangle$. Measure some observable $\hat{O}$. You repeat this protocol in each of many trials. The measurement yields different outcomes in different trials, according to quantum theory. The average amount of information that you learn about $\theta$ per trial is called the Fisher information.

Let’s change this protocol. After operating with the gate, measure another observable, $\hat{F}$, and postselect: If the $\hat{F}$ measurement yields a desirable outcome $f$, measure $\hat{O}$. If the $\hat{F}$-measurement doesn’t yield the desirable outcome, abort the trial, and begin again. If you choose $\hat{F}$ and $f$ adroitly, you’ll measure $\hat{O}$ only when the trial will provide oodles of information about $\theta$. You’ll save yourself many $\hat{O}$ measurements that would have benefited you little.2

Why does postselection help us? We could understand easily if the system were classical: The postselection would effectively improve the input state. To illustrate, let’s suppose that (i) a magnetic field implemented the gate and (ii) the input were metal or rubber. The magnetic field wouldn’t affect the rubber; measuring $\hat{O}$ in rubber trials would provide no information about the field. So you could spare yourself $\hat{O}$ measurements by postselecting on the system’s consisting of metal.

Postselection on a quantum system can defy this explanation. Consider optimizing your input state $| \psi \rangle$, beginning each trial with the quantum equivalent of metal. Postselection could still increase the average amount of information information provided about $\theta$ per trial. Postselection can enhance quantum metrology even when postselection can’t enhance the classical analogue.

David suspected that he could prove this result, using, as a mathematical tool, the quasiprobability that collaborators and I had defined. We fulfilled his prediction, with Hugo Lepage, Aleks Lasek, Seth Lloyd, and Crispin Barnes. Nature Communications published our paper last month. The work bridges the foundations of quantum theory with quantum metrology and quantum information theory—and, through that quasiprobability, string theory. David’s and my quantum quest continues, so keep an eye out for more theory from us, as well as a photonic experiment based on our first paper.

I still have my grandfather’s antique key. I never found a drawer, chest, or box that it opened. But I don’t mind. I have other mysteries to help unlock.

1The morning after my wedding this June, my husband and I found a bouquet ordered by David on our doorstep.

2Postselection has a catch: The $\hat{F}$ measurement has a tiny probability of yielding the desirable outcome. But, sometimes, measuring $\hat{O}$ costs more than preparing $| \psi \rangle$, performing the gate, and postselecting. For example, suppose that the system is a photon. A photodetector will measure $\hat{O}$. Some photodetectors have a dead time: After firing, they take a while to reset, to be able to fire again. The dead time can outweigh the cost of the beginning of the experiment.

# A quantum walk down memory lane

In elementary and middle school, I felt an affinity for the class three years above mine. Five of my peers had siblings in that year. I carpooled with a student in that class, which partnered with mine in holiday activities and Grandparents’ Day revues. Two students in that class stood out. They won academic-achievement awards, represented our school in science fairs and speech competitions, and enrolled in rigorous high-school programs.

Those students came to mind as I grew to know David Limmer. David is an assistant professor of chemistry at the University of California, Berkeley. He studies statistical mechanics far from equilibrium, using information theory. Though a theorist ardent about mathematics, he partners with experimentalists. He can pass as a physicist and keeps an eye on topics as far afield as black holes. According to his faculty page, I discovered while writing this article, he’s even three years older than I.

I met David in the final year of my PhD. I was looking ahead to postdocking, as his postdoc fellowship was fading into memory. The more we talked, the more I thought, I’d like to be like him.

I had the good fortune to collaborate with David on a paper published by Physical Review A this spring (as an Editors’ Suggestion!). The project has featured in Quantum Frontiers as the inspiration for a rewriting of “I’m a little teapot.”

We studied a molecule prevalent across nature and technologies. Such molecules feature in your eyes, solar-fuel-storage devices, and more. The molecule has two clumps of atoms. One clump may rotate relative to the other if the molecule absorbs light. The rotation switches the molecule from a “closed” configuration to an “open” configuration.

These molecular switches are small, quantum, and far from equilibrium; so modeling them is difficult. Making assumptions offers traction, but many of the assumptions disagreed with David. He wanted general, thermodynamic-style bounds on the probability that one of these molecular switches would switch. Then, he ran into me.

I traffic in mathematical models, developed in quantum information theory, called resource theories. We use resource theories to calculate which states can transform into which in thermodynamics, as a dime can transform into ten pennies at a bank. David and I modeled his molecule in a resource theory, then bounded the molecule’s probability of switching from “closed” to “open.” I accidentally composed a theme song for the molecule; you can sing along with this post.

That post didn’t mention what David and I discovered about quantum clocks. But what better backdrop for a mental trip to elementary school or to three years into the future?

I’ve blogged about autonomous quantum clocks (and ancient Assyria) before. Autonomous quantum clocks differ from quantum clocks of another type—the most precise clocks in the world. Scientists operate the latter clocks with lasers; autonomous quantum clocks need no operators. Autonomy benefits you if you want for a machine, such as a computer or a drone, to operate independently. An autonomous clock in the machine ensures that, say, the computer applies the right logical gate at the right time.

What’s an autonomous quantum clock? First, what’s a clock? A clock has a degree of freedom (e.g., a pair of hands) that represents the time and that moves steadily. When the clock’s hands point to 12 PM, you’re preparing lunch; when the clock’s hands point to 6 PM, you’re reading Quantum Frontiers. An autonomous quantum clock has a degree of freedom that represents the time fairly accurately and moves fairly steadily. (The quantum uncertainty principle prevents a perfect quantum clock from existing.)

Suppose that the autonomous quantum clock constitutes one part of a machine, such as a quantum computer, that the clock guides. When the clock is in one quantum state, the rest of the machine undergoes one operation, such as one quantum logical gate. (Experts: The rest of the machine evolves under one Hamiltonian.) When the clock is in another state, the rest of the machine undergoes another operation (evolves under another Hamiltonian).

Physicists have been modeling quantum clocks using the resource theory with which David and I modeled our molecule. The math with which we represented our molecule, I realized, coincided with the math that represents an autonomous quantum clock.

Think of the molecular switch as a machine that operates (mostly) independently and that contains an autonomous quantum clock. The rotating clump of atoms constitutes the clock hand. As a hand rotates down a clock face, so do the nuclei rotate downward. The hand effectively points to 12 PM when the switch occupies its “closed” position. The hand effectively points to 6 PM when the switch occupies its “open” position.

The nuclei account for most of the molecule’s weight; electrons account for little. They flit about the landscape shaped by the atomic clumps’ positions. The landscape governs the electrons’ behavior. So the electrons form the rest of the quantum machine controlled by the nuclear clock.

Experimentalists can create and manipulate these molecular switches easily. For instance, experimentalists can set the atomic clump moving—can “wind up” the clock—with ultrafast lasers. In contrast, the only other autonomous quantum clocks that I’d read about live in theory land. Can these molecules bridge theory to experiment? Reach out if you have ideas!

And check out David’s theory lab on Berkeley’s website and on Twitter. We all need older siblings to look up to.

# Up we go! or From abstract theory to experimental proposal

Mr. Mole is trapped indoors, alone. Spring is awakening outside, but he’s confined to his burrow. Birds are twittering, and rabbits are chattering, but he has only himself for company.

Sound familiar?

Spring—crocuses, daffodils, and hyacinths budding; leaves unfurling; and birds warbling—burst upon Cambridge, Massachusetts last month. The city’s shutdown vied with the season’s vivaciousness. I relieved the tension by rereading The Wind in the Willows, which I’ve read every spring since 2017.

Project Gutenberg offers free access to Kenneth Grahame’s 1908 novel. He wrote the book for children, but never mind that. Many masterpieces of literature happen to have been written for children.

One line in the novel demanded, last year, that I memorize it. On page one, Mole is cleaning his house beneath the Earth’s surface. He’s been dusting and whitewashing for hours when the spring calls to him. Life is pulsating on the ground and in the air above him, and he can’t resist joining the party. Mole throws down his cleaning supplies and tunnels upward through the soil: “he scraped and scratched and scrabbled and scrooged, and then he scrooged again and scrabbled and scratched and scraped.”

The quotation appealed to me not only because of its alliteration and chiasmus. Mole’s journey reminded me of research.

Take a paper that I published last month with Michael Beverland of Microsoft Research and Amir Kalev of the Joint Center for Quantum Information and Computer Science (now of the Information Sciences Institute at the University of Southern California). We translated a discovery from the abstract, mathematical language of quantum-information-theoretic thermodynamics into an experimental proposal. We had to scrabble, but we kept on scrooging.

Over four years ago, other collaborators and I uncovered a thermodynamics problem, as did two other groups at the same time. Thermodynamicists often consider small systems that interact with large environments, like a magnolia flower releasing its perfume into the air. The two systems—magnolia flower and air—exchange things, such as energy and scent particles. The total amount of energy in the flower and the air remains constant, as does the total number of perfume particles. So we call the energy and the perfume-particle number conserved quantities.

We represent quantum conserved quantities with matrices $Q_1$ and $Q_2$. We nearly always assume that, in this thermodynamic problem, those matrices commute with each other: $Q_1 Q_2 = Q_2 Q_1$. Almost no one mentions this assumption; we make it without realizing. Eliminating this assumption invalidates a derivation of the state reached by the small system after a long time. But why assume that the matrices commute? Noncommutation typifies quantum physics and underlies quantum error correction and quantum cryptography.

What if the little system exchanges with the large system thermodynamic quantities represented by matrices that don’t commute with each other?

Colleagues and I began answering this question, four years ago. The small system, we argued, thermalizes to near a quantum state that contains noncommuting matrices. We termed that state, $e^{ - \sum_\alpha \beta_\alpha Q_\alpha } / Z$, the non-Abelian thermal state. The $Q_\alpha$’s represent conserved quantities, and the $\beta_\alpha$’s resemble temperatures. The real number $Z$ ensures that, if you measure any property of the state, you’ll obtain some outcome. Our arguments relied on abstract mathematics, resource theories, and more quantum information theory.

Over the past four years, noncommuting conserved quantities have propagated across quantum-information-theoretic thermodynamics.1 Watching the idea take root has been exhilarating, but the quantum information theory didn’t satisfy me. I wanted to see a real physical system thermalize to near the non-Abelian thermal state.

Michael and Amir joined the mission to propose an experiment. We kept nosing toward a solution, then dislodging a rock that would shower dirt on us and block our path. But we scrabbled onward.

Imagine a line of ions trapped by lasers. Each ion contains the physical manifestation of a qubit—a quantum two-level system, the basic unit of quantum information. You can think of a qubit as having a quantum analogue of angular momentum, called spin. The spin has three components, one per direction of space. These spin components are represented by matrices $Q_x = S_x$, $Q_y = S_y$, and $Q_z = S_z$ that don’t commute with each other.

A couple of qubits can form the small system, analogous to the magnolia flower. The rest of the qubits form the large system, analogous to the air. I constructed a Hamiltonian—a matrix that dictates how the qubits evolve—that transfers quanta of all the spin’s components between the small system and the large. (Experts: The Heisenberg Hamiltonian transfers quanta of all the spin components between two qubits while conserving $S_{x, y, z}^{\rm tot}$.)

The Hamiltonian led to our first scrape: I constructed an integrable Hamiltonian, by accident. Integrable Hamiltonians can’t thermalize systems. A system thermalizes by losing information about its initial conditions, evolving to a state with an exponential form, such as $e^{ - \sum_\alpha \beta_\alpha Q_\alpha } / Z$. We clawed at the dirt and uncovered a solution: My Hamiltonian coupled together nearest-neighbor qubits. If the Hamiltonian coupled also next-nearest-neighbor qubits, or if the ions formed a 2D or 3D array, the Hamiltonian would be nonintegrable.

We had to scratch at every stage—while formulating the setup, preparation procedure, evolution, measurement, and prediction. But we managed; Physical Review E published our paper last month. We showed how a quantum system can evolve to the non-Abelian thermal state. Trapped ions, ultracold atoms, and quantum dots can realize our experimental proposal. We imported noncommuting conserved quantities in thermodynamics from quantum information theory to condensed matter and atomic, molecular, and optical physics.

As Grahame wrote, the Mole kept “working busily with his little paws and muttering to himself, ‘Up we go! Up we go!’ till at last, pop! his snout came out into the sunlight and he found himself rolling in the warm grass of a great meadow.”

1See our latest paper’s introduction for references. https://journals.aps.org/pre/abstract/10.1103/PhysRevE.101.042117

# Sense, sensibility, and superconductors

Jonathan Monroe disagreed with his PhD supervisor—with respect. They needed to measure a superconducting qubit, a tiny circuit in which current can flow forever. The qubit emits light, which carries information about the qubit’s state. Jonathan and Kater intensify the light using an amplifier. They’d fabricated many amplifiers, but none had worked. Jonathan suggested changing their strategy—with a politeness to which Emily Post couldn’t have objected. Jonathan’s supervisor, Kater Murch, suggested repeating the protocol they’d performed many times.

“That’s the definition of insanity,” Kater admitted, “but I think experiment needs to involve some of that.”

I watched the exchange via Skype, with more interest than I’d have watched the Oscars with. Someday, I hope, I’ll be able to weigh in on such a debate, despite working as a theorist. Someday, I’ll have partnered with enough experimentalists to develop insight.

I’m partnering with Jonathan and Kater on an experiment that coauthors and I proposed in a paper blogged about here. The experiment centers on an uncertainty relation, an inequality of the sort immortalized by Werner Heisenberg in 1927. Uncertainty relations imply that, if you measure a quantum particle’s position, the particle’s momentum ceases to have a well-defined value. If you measure the momentum, the particle ceases to have a well-defined position. Our uncertainty relation involves weak measurements. Weakly measuring a particle’s position doesn’t disturb the momentum much and vice versa. We can interpret the uncertainty in information-processing terms, because we cast the inequality in terms of entropies. Entropies, described here, are functions that quantify how efficiently we can process information, such as by compressing data. Jonathan and Kater are checking our inequality, and exploring its implications, with a superconducting qubit.

I had too little experience to side with Jonathan or with Kater. So I watched, and I contemplated how their opinions would sound if expressed about theory. Do I try one strategy again and again, hoping to change my results without changing my approach?

At the Perimeter Institute for Theoretical Physics, Masters students had to swallow half-a-year of course material in weeks. I questioned whether I’d ever understand some of the material. But some of that material resurfaced during my PhD. Again, I attended lectures about Einstein’s theory of general relativity. Again, I worked problems about observers in free-fall. Again, I calculated covariant derivatives. The material sank in. I decided never to question, again, whether I could understand a concept. I might not understand a concept today, or tomorrow, or next week. But if I dedicate enough time and effort, I chose to believe, I’ll learn.

My decision rested on experience and on classes, taught by educational psychologists, that I’d taken in college. I’d studied how brains change during learning and how breaks enhance the changes. Sense, I thought, underlay my decision—though expecting outcomes to change, while strategies remain static, sounds insane.

Does sense underlie Kater’s suggestion, likened to insanity, to keep fabricating amplifiers as before? He’s expressed cynicism many times during our collaboration: Experiment needs to involve some insanity. The experiment probably won’t work for a long time. Plenty more things will likely break.

Jonathan and I agree with him. Experiments have a reputation for breaking, and Kater has a reputation for knowing experiments. Yet Jonathan—with professionalism and politeness—remains optimistic that other methods will prevail, that we’ll meet our goals early. I hope that Jonathan remains optimistic, and I fancy that Kater hopes, too. He prophesies gloom with a quarter of a smile, and his record speaks against him: A few months ago, I met a theorist who’d collaborated with Kater years before. The theorist marveled at the speed with which Kater had operated. A theorist would propose an experiment, and boom—the proposal would work.

Perhaps luck smiled upon the implementation. But luck dovetails with the sense that underlies Kater’s opinion: Experiments involve factors that you can’t control. Implement a protocol once, and it might fail because the temperature has risen too high. Implement the protocol again, and it might fail because a truck drove by your building, vibrating the tabletop. Implement the protocol again, and it might fail because you bumped into a knob. Implement the protocol a fourth time, and it might succeed. If you repeat a protocol many times, your environment might change, changing your results.

Sense underlies also Jonathan’s objections to Kater’s opinions. We boost our chances of succeeding if we keep trying. We derive energy to keep trying from creativity and optimism. So rebelling against our PhD supervisors’ sense is sensible. I wondered, watching the Skype conversation, whether Kater the student had objected to prophesies of doom as Jonathan did. Kater exudes the soberness of a tenured professor but the irreverence of a Californian who wears his hair slightly long and who tattooed his wedding band on. Science thrives on the soberness and the irreverence.

Who won Jonathan and Kater’s argument? Both, I think. Last week, they reported having fabricated amplifiers that work. The lab followed a protocol similar to their old one, but with more conscientiousness.

I’m looking forward to watching who wins the debate about how long the rest of the experiment takes. Either way, check out Jonathan’s talk about our experiment if you attend the American Physical Society’s March Meeting. Jonathan will speak on Thursday, March 5, at 12:03, in room 106. Also, keep an eye out for our paper—which will debut once Jonathan coaxes the amplifier into synching with his qubit.

# On the merits of flatworm reproduction

On my right sat a quantum engineer. She was facing a melanoma specialist who works at a medical school. Leftward of us sat a networks expert, a flatworm enthusiast, and a condensed-matter theorist.

Farther down sat a woman who slices up mouse brains.

Welcome to “Coherent Spins in Biology,” a conference that took place at the University of California, Los Angeles (UCLA) this past December. Two southern Californians organized the workshop: Clarice Aiello heads UCLA’s Quantum Biology Tech lab. Thorsten Ritz, of the University of California, Irvine, cofounded a branch of quantum biology.

Quantum biology served as the conference’s backdrop. According to conventional wisdom, quantum phenomena can’t influence biology significantly: Biological systems have high temperatures, many particles, and fluids. Quantum phenomena, such as entanglement (a relationship that quantum particles can share), die quickly under such conditions.

Yet perhaps some survive. Quantum biologists search for biological systems that might use quantum resources. Then, they model and measure the uses and resources. Three settings (at least) have held out promise during the past few decades: avian navigation, photosynthesis, and olfaction. You can read about them in this book, cowritten by a conference participant for the general public. I’ll give you a taste (or a possibly quantum smell?) by sketching the avian-navigation proposal, developed by Thorsten and colleagues.

Birds migrate southward during the autumn and northward during the spring. How do they know where to fly? At least partially by sensing the Earth’s magnetic field, which leads compass needles to point northward. How do birds sense the field?

Possibly with a protein called “cryptochrome.” A photon (a particle of light) could knock an electron out of part of the protein and into another part. Each part would have one electron that lacked a partner. The electrons would share entanglement. One electron would interact with the Earth’s magnetic field differently than its partner, because its surroundings would differ. (Experts: The electrons would form a radical pair. One electron would neighbor different atoms than the other, so the electron would experience a different local magnetic field. The discrepancy would change the relative phase between the electrons’ spins.) The discrepancy could affect the rate at which the chemical system could undergo certain reactions. Which reactions occur could snowball into large and larger effects, eventually signaling the brain about where the bird should fly.

Quantum mechanics and life rank amongst the universe’s mysteries. How could a young researcher resist the combination? A postdoc warned me away, one lunchtime at the start of my PhD. Quantum biology had enjoyed attention several years earlier, he said, but noise the obscured experimental data. Controversy marred the field.

I ate lunch with that postdoc in 2013. Interest in quantum biology is reviving, as evidenced in the conference. Two reasons suggested themselves: new technologies and new research avenues. For example, Thorsten described the disabling and deletion of genes that code for cryptochrome. Such studies require years’ more work but might illuminate whether cryptochrome affects navigation.

The keynote speaker, Harvard’s Misha Lukin, illustrated new technologies and new research avenues. Misha’s lab has diamonds that contain quantum defects, which serve as artificial atoms. The defects sense tiny magnetic fields and temperatures. Misha’s group applies these quantum sensors to biology problems.

For example, different cells in an embryo divide at different times. Imagine reversing the order in which the cells divide. Would the reversal harm the organism? You could find out by manipulating the temperatures in different parts of the embryo: Temperature controls the rate at which cells divide.

Misha’s team injected nanoscale diamonds into a worm embryo. (See this paper for a related study.) The diamonds reported the temperature at various points in the worm. This information guided experimentalists who heated the embryo with lasers.

The manipulated embryos grew into fairly normal adults. But their cells, and their descendants’ cells, cycled through the stages of life slowly. This study exemplified, to me, one of the most meaningful opportunities for quantum physicists interested in biology: to develop technologies and analyses that can answer biology questions.

I mentioned, in an earlier blog post, another avenue emerging in quantum biology: Physicist Matthew Fisher proposed a mechanism by which entanglement might enhance coordinated neuron firing. My collaborator Elizabeth Crosson and I analyzed how the molecules in Matthew’s proposal—Posner clusters—could process quantum information. The field of Posner quantum biology had a population of about two, when Elizabeth and I entered, and I wondered whether anyone would join us.

The conference helped resolve my uncertainty. Three speakers (including me) presented work based on Matthew’s; two other participants were tilling the Posner soil; and another speaker mentioned Matthew’s proposal. The other two Posner talks related data from three experiments. The experimentalists haven’t finished their papers, so I won’t share details. But stay tuned.

Posner molecule (image by Swift et al.)

Clarice and Thorsten’s conference reminded me of a conference I’d participated in at the end of my PhD: Last month, I moonlighted as a quantum biologist. In 2017, I moonlighted as a quantum-gravity theorist. Two years earlier, I’d been dreaming about black holes and space-time. At UCLA, I was finishing the first paper I’ve coauthored with biophysicists. What a toolkit quantum information theory and thermodynamics provide, that it can unite such disparate fields.

The contrast—on top of what I learned at UCLA—filled my mind for weeks. And reminded me of the description of asexual reproduction that we heard from the conference’s flatworm enthusiast. According to Western Michigan University’s Wendy Beane, a flatworm “glues its butt down, pops its head off, and grows a new one. Y’know. As one does.”

I hope I never flinch from popping my head off and growing a new one—on my quantum-information-thermodynamics spine—whenever new science calls for figuring out.

With thanks to Clarice, Thorsten, and UCLA for their invitation and hospitality.

# An equation fit for a novel

Archana Kamal was hunting for an apartment in Cambridge, Massachusetts. She was moving MIT, to work as a postdoc in physics. The first apartment she toured had housed John Updike, during his undergraduate career at Harvard. No other apartment could compete; Archana signed the lease.

The apartment occupied the basement of a red-brick building covered in vines. The rooms spanned no more than 350 square feet. Yet her window opened onto the neighbors’ garden, whose leaves she tracked across the seasons. And Archana cohabited with history.

She’s now studying the universe’s history, as an assistant professor of physics at the University of Massachusetts Lowell. The cosmic microwave background (CMB) pervades the universe. The CMB consists of electromagnetic radiation, or light. Light has particle-like properties and wavelike properties. The wavelike properties include wavelength, the distance between successive peaks. Long-wavelength light includes red light, infrared light, and radio waves. Short-wavelength light includes blue light, ultraviolet light, and X-rays. Light of one wavelength and light of another wavelength are said to belong to different modes.

Does the CMB have nonclassical properties, impossible to predict with classical physics but (perhaps) predictable with quantum theory? The CMB does according to the theory of inflation. According to the theory, during a short time interval after the Big Bang, the universe expanded very quickly: Spacetime stretched. Inflation explains features of our universe, though we don’t know what mechanism would have effected the expansion.

According to inflation, around the Big Bang time, all the light in the universe crowded together. The photons (particles of light) interacted, entangling (developing strong quantum correlations). Spacetime then expanded, and the photons separated. But they might retain entanglement.

Detecting that putative entanglement poses challenges. For instance, the particles that you’d need to measure could produce a signal too weak to observe. Cosmologists have been scratching their heads about how to observe nonclassicality in the CMB. One team—Nishant Agarwal at UMass Lowell and Sarah Shandera at Pennsylvania State University—turned to Archana for help.

Archana studies the theory of open quantum systems, quantum systems that interact with their environments. She thinks most about systems such as superconducting qubits, tiny circuits with which labs are building quantum computers. But the visible universe constitutes an open quantum system.

We can see only part of the universe—or, rather, only part of what we believe is the whole universe. Why? We can see only stuff that’s emitted light that has reached us, and light has had only so long to travel. But the visible universe interacts (we believe) with stuff we haven’t seen. For instance, according to the theory of inflation, that rapid expansion stretched some light modes’ wavelengths. Those wavelengths grew longer than the visible universe. We can’t see those modes’ peak-to-peak variations or otherwise observe the modes, often called “frozen.” But the frozen modes act as an environment that exchanges information and energy with the visible universe.

We describe an open quantum system’s evolution with a quantum master equation, which I blogged about four-and-a-half years ago. Archana and collaborators constructed a quantum master equation for the visible universe. The frozen modes, they found, retain memories of the visible universe. (Experts: the bath is non-Markovian.) Next, they need to solve the equation. Then, they’ll try to use their solution to identify quantum observables that could reveal nonclassicality in the CMB.

Frozen modes

Archana’s project caught my fancy for two reasons. First, when I visited her in October, I was collaborating on a related project. My coauthors and I were concocting a scheme for detecting nonclassical correlations in many-particle systems by measuring large-scale properties. Our paper debuted last month. It might—with thought and a dash of craziness—be applied to detect nonclassicality in the CMB. Archana’s explanation improved my understanding of our scheme’s potential.

Second, Archana and collaborators formulated a quantum master equation for the visible universe. A quantum master equation for the visible universe. The phrase sounded romantic to me.1 It merited a coauthor who’d seized on an apartment lived in by a Pulitzer Prize-winning novelist.

Archana’s cosmology and Updike stories reminded me of one reason why I appreciate living in the Boston area: History envelops us here. Last month, while walking to a grocery, I found a sign that marks the building in which the poet e. e. cummings was born. My walking partner then generously tolerated a recitation of cummings’s “anyone lived in a pretty how town.” History enriches our lives—and some of it might contain entanglement.

1It might sound like gobbledygook to you, if I’ve botched my explanations of the terminology.

With thanks to Archana and the UMass Lowell Department of Physics and Applied Physics for their hospitality and seminar invitation.

# The paper that begged for a theme song

A year ago, the “I’m a little teapot” song kept playing in my head.

I was finishing a collaboration with David Limmer, a theoretical chemist at the University of California Berkeley. David studies quantum and classical systems far from equilibrium, including how these systems exchange energy and information with their environments. Example systems include photoisomers.

A photoisomer is a molecular switch. These switches appear across nature and technologies. We have photoisomers in our eyes, and experimentalists have used photoisomers to boost solar-fuel storage. A photoisomer has two functional groups, or collections of bonded atoms, attached to a central axis.

Your average-Joe photoisomer spends much of its life in equilibrium, exchanging heat with room-temperature surroundings. The molecule has the shape above, called the cis configuration. Imagine shining a laser or sunlight on the photoisomer. The molecule can absorb a photon, or particle of light, gaining energy. The energized switch has the opportunity to switch: One chemical group can rotate downward. The molecule will occupy its trans configuration.

The molecule now has more energy than it had while equilibrium, albeit less energy than it had right after absorbing the photon. The molecule can remain in this condition for a decent amount of time. (Experts: The molecule occupies a metastable state.) That is, the molecule can store sunlight. For that reason, experimentalists at Harvard and MIT attached photoisomers to graphene nanotubules, improving the nanotubules’ storage of solar fuel.

With what probability does a photoisomer switch upon absorbing a photon? This question has resisted easy answering, because photoisomers prove difficult to model: They’re small, quantum, and far from equilibrium. People have progressed by making assumptions, but such assumptions can lack justifications or violate physical principles. David wanted to derive a simple, general bound—of the sort in which thermodynamicists specialize—on a photoisomer’s switching probability.

He had a hunch as to how he could derive such a bound. I’ve blogged, many times, about thermodynamic resource theories. Thermodynamic resource theories are simple models, developed in quantum information theory, for exchanges of heat, particles, information, and more. These models involve few assumptions: the conservation of energy, quantum theory, and, to some extent, the existence of a large environment (Markovianity). With such a model, David suspected, he might derive his bound.

I knew nothing about photoisomers when I met David, but I knew about thermodynamic resource theories. I’d contributed to their development, to the theorems that have piled up in the resource-theory corner of quantum information theory. Then, the corner had given me claustrophobia. Those theorems felt so formal, abstract, and idealized. Formal, abstract theory has drawn me ever since I started studying physics in college. But did resource theories model physical reality? Could they impact science beyond our corner of quantum information theory? Did resource theories matter?

I called for connecting thermodynamic resource theories to physical reality four years ago, in a paper that begins with an embarrassing story about me. Resource theorists began designing experiments whose results should agree with our theorems. Theorists also tried to improve the accuracy with which resource theories model experimentalists’ limitations. See David’s and my paper for a list of these achievements. They delighted me, as a step toward the broadening of resource theories’ usefulness.

Like any first step, this step pointed toward opportunities. Experiments designed to test our theorems essentially test quantum mechanics. Scientists have tested quantum mechanics for decades; we needn’t test it much more. Such experimental proposals can push experimentalists to hone their abilities, but I hoped that the community could accomplish more. We should be able to apply resource theories to answer questions cultivated in other fields, such as condensed matter and chemistry. We should be useful to scientists outside our corner of quantum information.

David’s idea lit me up like photons on a solar-fuel-storage device. He taught me about photoisomers, I taught him about resource theories, and we derived his bound. Our proof relies on the “second laws of thermodynamics.” These abstract resource-theory results generalize the second law of thermodynamics, which helps us understand why time flows in only one direction. We checked our bound against numerical simulations (experts: of Lindbladian evolution). Our bound is fairly tight if the photoisomer has a low probability of absorbing a photon, as in the Harvard-MIT experiment.

Experts: We also quantified the photoisomer’s coherences relative to the energy eigenbasis. Coherences can’t boost the switching probability, we concluded. But, en route to this conclusion, we found that the molecule is a natural realization of a quantum clock. Our quantum-clock modeling extends to general dissipative Landau-Zener transitions, prevalent across condensed matter and chemistry.

As I worked on our paper one day, a jingle unfolded in my head. I recognized the tune first: “I’m a little teapot.” I hadn’t sung that much since kindergarten, I realized. Lyrics suggested themselves:

I’m a little isomer
with two hands.
Here is my cis pose;
here is my trans.

Stand me in the sunlight;
watch me spin.
I’ll keep solar
energy in!

The song lodged itself in my head for weeks. But if you have to pay an earworm to collaborate with David, do.

# Quantum Error Correction with Molecules

In the previous blog post (titled, “On the Coattails of Quantum Supremacy“) we started with Google and ended up with molecules! I also mentioned a recent paper by John Preskill, Jake Covey, and myself (see also this videoed talk) where we assume that, somewhere in the (near?) future, experimentalists will be able to construct quantum superpositions of several orientations of molecules or other rigid bodies. Next, I’d like to cover a few more details on how to construct error-correcting codes for anything from classical bits in your phone to those future quantum computers, molecular or otherwise.

# Classical error correction: the basics

Error correction is concerned with the design of an encoding that allows for protection against noise. Let’s say we want to protect one classical bit, which is in either “0” or “1”. If the bit is say in “0”, and the environment (say, the strong magnetic field from a magnet you forgot was laying next to your hard drive) flipped it to “1” without our knowledge, an error would result (e.g., making your phone think you swiped right!)

Now let’s encode our single logical bit into three physical bits, whose $2^3=8$ possible states are represented by the eight corners of the cube below. Let’s encode the logical bit as “0” —> 000 and “1” —> 111, corresponding to the corners of the cube marked by the black and white ball, respectively. For our (local) noise model, we assume that flips of only one of the three physical bits are more likely to occur than flips of two or three at the same time.

Error correction is, like many Hollywood movies, an origin story. If, say, the first bit flips in our above code, the 000 state is mapped to 100, and 111 is mapped to 011. Since we have assumed that the most likely error is a flip of one of the bits, we know upon observing that 100 must have come from the clean 000, and 011 from 111. Thus, in either case of the logical bit being “0” or “1”, we can recover the information by simply observing which state the majority of the bits are in. The same things happen when the second or third bits flip. In all three cases, the logical “0” state is mapped to one of its three neighboring points (above, in blue) while the logical “1” is mapped to its own three points, which, crucially, are distinct from the neighbors of “0”. The set of points $\{000,100,010,001\}$ that are closer to 000 than to 111 is called a Voronoi tile.

Now, let’s adapt these ideas to molecules. Consider the rotational states of a dumb-bell molecule consisting of two different atoms. (Let’s assume that we have frozen this molecule to the point that the vibration of the inter-atomic bond is limited, essentially creating a fixed distance between the two atoms.) This molecule can orient itself in any direction, and each such orientation can be represented as a point $\mathbf{v}$ on the surface of a sphere. Now let us encode a classical bit using the north and south poles of this sphere (represented in the picture below as a black and a white ball, respectively). The north pole of the sphere corresponds to the molecule being parallel to the z-axis, while the south pole corresponds to the molecule being anti-parallel.

This time, the noise consists of small shifts in the molecule’s orientation. Clearly, if such shifts are small, the molecule just wiggles a bit around the z-axis. Such wiggles still allow us to infer that the molecule is (mostly) parallel and anti-parallel to the axis, as long as they do not rotate the molecule all the way past the equator. Upon such correctable rotations, the logical “0” state — the north pole — is mapped to a point in the northern hemisphere, while logical “1” — the south pole — is mapped to a point in the southern hemisphere. The northern hemisphere forms a Voronoi tile of the logical “0” state (blue in the picture), which, along with the corresponding tile of the logical “1” state (the southern hemisphere), tiles the entire sphere.

Quantum error correction

To upgrade these ideas to the quantum realm, recall that this time we have to protect superpositions. This means that, in addition to shifting our quantum logical state to other states as before, noise can also affect the terms in the superposition itself. Namely, if, say, the superposition is equal — with an amplitude of $+1/\sqrt{2}$ in “0” and $+1/\sqrt{2}$ in “1” — noise can change the relative sign of the superposition and map one of the amplitudes to $-1/\sqrt{2}$. We didn’t have to worry about such sign errors before, because our classical information would always be the definite state of “0” or “1”. Now, there are two effects of noise to worry about, so our task has become twice as hard!

Not to worry though. In order to protect against both sources of noise, all we need to do is effectively stagger the above constructions. Now we will need to design a logical “0” state which is itself a superposition of different points, with each point separated from all of the points that are superimposed to make the logical “1” state.

Diatomic molecules: For the diatomic molecule example, consider superpositions of all four corners of two antipodal tetrahedra for the two respective logical states.

The logical “0” state for the quantum code is now itself a quantum superposition of orientations of our diatomic molecule corresponding to the four black points on the sphere to the left (the sphere to the right is a top-down view). Similarly, the logical “1” quantum state is a superposition of all orientations corresponding to the white points.

Each orientation (black or white point) present in our logical states rotates under fluctuations in the position of the molecule. However, the entire set of orientations for say logical “0” — the tetrahedron — rotates rigidly under such rotations. Therefore, the region from which we can successfully recover after rotations is fully determined by the Voronoi tile of any one of the corners of the tetrahedron. (Above, we plot the tile for the point at the north pole.) This cell is clearly smaller than the one for classical north-south-pole encoding we used before. However, the tetrahedral code now provides some protection against phase errors — the other type of noise that we need to worry about if we are to protect quantum information. This is an example of the trade-off we must make in order to protect against both types of noise; a licensed quantum mechanic has to live with such trade-offs every day.

Oscillators: Another example of a quantum encoding is the GKP encoding in the phase space of the harmonic oscillator. Here, we have at our disposal the entire two-dimensional plane indexing different values of position and momentum. In this case, we can use a checkerboard approach, superimposing all points at the centers of the black squares for the logical “0” state, and similarly all points at the centers of the white squares for the logical “1”. The region depicting correctable momentum and position shifts is then the Voronoi cell of the point at the origin: if a shift takes our central black point to somewhere inside the blue square, we know (most likely) where that point came from! In solid state circles, the blue square is none other than the primitive or unit cell of the lattice consisting of points making up both of the logical states.

Asymmetric molecules (a.k.a. rigid rotors): Now let’s briefly return to molecules. Above, we considered diatomic molecules that had a symmetry axis, i.e., that were left unchanged under rotations about the axis that connects the two atoms. There are of course more general molecules out there, including ones that are completely asymmetric under any possible (proper) 3D rotation (see figure below for an example).

BONUS: There is a subtle mistake relating to the geometry of the rotation group in the labeling of this figure. Let me know if you can find it in the comments!

All of the orientations of the asymmetric molecule, and more generally a rigid body, can no longer be parameterized by the sphere. They can be parameterized by the 3D rotation group $\mathsf{SO}(3)$: each orientation of an asymmetric molecule is labeled by the 3D rotation necessary to obtain said orientation from a reference state. Such rotations, and in turn the orientations themselves, are parameterized by an axis $\mathbf{v}$ (around which to rotate) and an angle $\omega$ (by which one rotates). The rotation group $\mathsf{SO}(3)$ luckily can still be viewed by humans on a sheet of paper. Namely, $\mathsf{SO}(3)$ can be thought of as a ball of radius $\pi$ with opposite points identified. The direction of each vector $\omega\mathbf{v}$ lying inside the ball corresponds to the axis of rotation, while the length corresponds to the angle. This may take some time to digest, but it’s not crucial to the story.

So far we’ve looked at codes defined on cubes of bits, spheres, and phase-space lattices. Turns out that even $\mathsf{SO}(3)$ can house similar encodings! In other words, $\mathsf{SO}(3)$ can also be cut up into different Voronoi tiles, which in turn can be staggered to create logical “0” and “1” states consisting of different molecular orientations. There are many ways to pick such states, corresponding to various subgroups of $\mathsf{SO}(3)$. Below, we sketch two sets of black/white points, along with the Voronoi tile corresponding to the rotations that are corrected by each encoding.

Voronoi tiles of the black point at the center of the ball representing the 3D rotation group, for two different molecular codes. This and the Voronoi cells corresponding to the other points tile together to make up the entire ball. 3D printing all of these tiles would make for cool puzzles!

In closing…

Achieving supremacy was a big first step towards making quantum computing a practical and universal tool. However, the largest obstacles still await, namely handling superposition-poisoning noise coming from the ever-curious environment. As quantum technologies advance, other possible routes for error correction are by encoding qubits in harmonic oscillators and molecules, alongside the “traditional” approach of using arrays of physical qubits. Oscillator and molecular qubits possess their own mechanisms for error correction, and could prove useful (granted that the large high-energy space required for the procedures to work can be accessed and controlled). Even though molecular qubits are not yet mature enough to be used in quantum computers, we have at least outlined a blueprint for how some of the required pieces can be built. We are by no means done however: besides an engineering barrier, we need to further develop how to run robust computations on these exotic spaces.

Author’s note: I’d like to acknowledge Jose Gonzalez for helping me immensely with the writing of this post, as well as for drawing the comic panels in the previous post. The figures above were made possible by Mathematica 12.